Ongoing efforts in Down syndrome cognitive research are described in this article from the NY Times Sunday magazine. The article is centered primarily on Dr. Alberto Costa and his quest to help his daughter, Tyche, and all others with Down syndrome. Also included in the article are contributions from researchers Drs. Roger Reeves, Craig Garner, and William Mobley, and a discussion on NIH funding priorities. The Trisomy 21 Translational Research Parity Act of 2009 was introduced to intensify efforts in research related to Down syndrome. RDS continues to encourage its supporters to contact their congressional representatives and urge them to support this important bill.